Composition : Levosalbutamol 1.25mg + Budesonide 0.5mg per Respule
Form : Inhalation Suspension
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Pack : 10 x 5 x 2ml
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Type : Combipack Respules
Description : Activation of β2 adrenergic receptors on airway smooth muscle leads to the activation of adenylate cyclase and to an increase in the intracellular concentration of cyclic AMP resulting the activation of protein kinase A, which in turn, inhibits the phosphorylation of myosin and lowers intracellular ionic calcium concentrations, Hence causes muscle relaxation.
Levosalbutamol being a functional short-acting β2 adrenergic receptor agonist, relaxes the smooth muscles from the trachea to the terminal bronchioles. Increased cyclic AMP concentrations are also associated with the inhibition of the release of mediators from mast cells in the airways, irrespective of the spasmogen involved, thereby protecting against all bronchoconstrictor challenges.
Budesonide is a potent glucocorticoid that binds with high affinity to the glucocorticoid receptor. It has a high ratio of topical to systemic activity. Budesonide is used to control and prevent symptoms such as wheezing, shortness of breath caused by asthma. Used as maintenance treatment of asthma and as a prophylactic therapy
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Budesonide 0.5mg Levosalbutamol 1.25mg