Description : Cilnidipine signficantly decreased the 24 h blood pressure by 6.5 1.7 mm Hg systolic (mean s.e.mean; P>0.01) and 5.0 1.1 mmHg diastolic (P > 0.01), whereas Cilnidipine did not change heart rate or any indices of power spectral components - Br J Clin Pharmacol. Dec 2000; 50(6): 615-620
There was no correlation between the degree of daytime SBP change and that of daytime PR change after amlodipine treatement (r=-0.08, n.s.) but there was a significant negative correlation between the degree of daytime SBP change and that of day-time PR change after cilnidipine treatment (r=-0.27, p<0.05). N-type calcium channel blockade by Cilnidipine may not cause reflex tachycardia, and may be useful for hypertensive treatment - Hypertens Res. 2005 Dec; 28(12): 1003-8
Description : As typically prescribed, chlorthalidone in older adults was not associated with fewer adverse cardiovascular events or deaths than hydrochlorothiazide - Department of Internal Medicine (Cardiology), St Louis University School of Medicine (J.D.C.), St. Louis.
Hypertension is the leading cause of morality, resulting from coronary heart disease and stroke, affects more than 100 million adults in India. If apply the current rate will be a 42% increase in number of deaths by 2030 - Ann Internm Med. 2013; 158(6):477-455
Description : The study indicates that unlike Amlodipine, Cilnidipine which inhibits L-and N-type calcium channels will be useful for patients with hypertension and cardiovascular disease, diabetes mellitus or renal disease and proves to be a better alternative to existing calcium channel blockers.- Int J Basic Clin Pharmacol. 2013; 2(2): 160-164.
Description : The rcommended dose of candesartan in heart failure is 4mg/day with a target dose of 32mg by doubling the dose in 2 2weekly - Cardiology News; Jul, 2005
-The onset is usually within 2-20 weeks of starting therapy. Rarre instance of clincally apparent acute liver injury have been reproted in association withcandesartan therapy - Hepatotoxicity; http/livertox,nih.gov/index.html
-Renal vascular resistance and labumin excretion were reduced following treatement with candesartan.Glucose homeostasis and lipid metabolism were not affected by treatmentin patients with type 2 diabetes mellitus. Candesartan is well tolerated and is not associated with cough - Drugs 2002;62(8):1253-87
Description : Reno-Protection:
-By triple calcium channel blocking activity, dilates Afferent and Efferent arterioles reduces glomerular pressure.
-Prevents the progression of Reno parenchymal hpertension and nephropathy by increasing NO fromation in the renal Parenchyma.
-Exerts Natriuretic effect.
-Benidipine partially inhibits angiotensin II induced upregulation of the mRNAs and shows Ca2 + influx inhibitory activities for aldosterone production.
Cardio Pretction
-Benidipine attenuates the extent of ischemia through NO-dependent mechanism.
-Benidipine reduces left ventricular mass and normalized systemic collagen type degradation abnormalities in essential hypertensive patients with severe LVH.
-Benidipine increases in the plasma levels of CGRP in the patients with essential hypertension.
-Benidipine hydrochloride decreases oxidative stress."
