Composition : Tritropium Bromide 9mcg Per Actuation
Form : Inhaler
/ Pack : 1 x 1's
/ Type : 120 Metered Doses
Description : : In large randomized clinical trials enrolling patients with moderate to severe asthma, add-on therapy with Tiotropium has demonstrated to be efficacious in improving lung function, decreasing risk of exacerbation and slowing the worsening of disease In view of the numerous ancillary effects acting on inflammation, airway remodeling, mucus production and cough reflex, along with the good safety profile and the broad spectrum of efficacy demonstrated in different disease phenotypes, tiotropium can represent a beneficial alternative in the therapeutic management of poorly controlled asthma - Multidiscip Respir Med 12, 12 (2017).
Description : Dextromethorphan HBr is a semi-synthetic morphinan analogue, shows high affinity to several regions of the brain, including the medullary cough center thus widely used as an anti-tussives. Hence prevents unproductive coughing.
Chlorpheniramine Maleate is a synthetic alkylamine derivative acts as a competitive H1- receptor antagonist and displays anticholinergic and mild sedative effects as well.
Phenylephrine HCl is an alpha-1 adrenergic agonist causes vasoconstriction in the management of nasal congestion.
/ Pack : 10 x 5 x 2.5ml
/ Type : Combipack Respules
Description : Activation of β2 adrenergic receptors on airway smooth muscle leads to the activation of adenylate cyclase and to an increase in the intracellular concentration of cyclic AMP resulting the activation of protein kinase A, which in turn, inhibits the phosphorylation of myosin and lowers intracellular ionic calcium concentrations, Hence causes muscle relaxation. Levosalbutamol being a functional short-acting β2 adrenergic receptor agonist, relaxes the smooth muscles from the trachea to the terminal bronchioles. Increased cyclic AMP concentrations are also associated with the inhibition of the release of mediators from mast cells in the airways, irrespective of the spasmogen involved, thereby protecting against all bronchoconstrictor challenges.
Composition : Levosalbutamol 1.25mg + Budesonide 0.5mg per Respule
Form : Inhalation Suspension
/ Pack : 10 x 5 x 2ml
/ Type : Combipack Respules
Description : Activation of β2 adrenergic receptors on airway smooth muscle leads to the activation of adenylate cyclase and to an increase in the intracellular concentration of cyclic AMP resulting the activation of protein kinase A, which in turn, inhibits the phosphorylation of myosin and lowers intracellular ionic calcium concentrations, Hence causes muscle relaxation. Levosalbutamol being a functional short-acting β2 adrenergic receptor agonist, relaxes the smooth muscles from the trachea to the terminal bronchioles. Increased cyclic AMP concentrations are also associated with the inhibition of the release of mediators from mast cells in the airways, irrespective of the spasmogen involved, thereby protecting against all bronchoconstrictor challenges.
Budesonide is a potent glucocorticoid that binds with high affinity to the glucocorticoid receptor. It has a high ratio of topical to systemic activity. Budesonide is used to control and prevent symptoms such as wheezing, shortness of breath caused by asthma. Used as maintenance treatment of asthma and as a prophylactic therapy
Form : Respirator Suspension
/ Pack : 5 x 5 x 2ml
/ Type : Combipack Respules
Description : Budesonide is a potent glucocorticoid that binds with high affinity to the glucocorticoid receptor. It has a high ratio of topical to systemic activity. Budesonide is used to control and prevent symptoms such as wheezing, shortness of breath caused by asthma. Used as maintenance treatment of asthma and as a prophylactic therapy in children 12 months to 8 years of age
Composition : Formoterol Fumarate 6mcg + Budesonide 400mcg Per Actuation
Form : Inhaler
/ Pack : 1 X 1's
/ Type : 120 Metered Doses
Description : Formoterol is a very potent, long-acting, beta-2 adrenoceptor-agonist with a high intrinsic activity and a rapid onset of action Where as Budesonide is a potent glucocorticoid that binds with high affinity to the glucocorticoid receptor. It has a high ratio of topical to systemic activity. The combination medicine has different modes of action and show additive effects in terms of reduction of asthma exacerbations thus used to control and prevent the symptoms of asthma in adults and children above 6 years old. Formoterol & Budesonide is also used to help control the symptoms of chronic obstructive pulmonary disease (COPD), including chronic bronchitis
Form : Capsules
/ Pack : 10 x 10's
/ Type : ALU-ALU
Description : Acebrophylline is an airway mucus regulator with antiinflammatory action. The drug's approach involves several points of attack in obstructive airway disease. The molecule contains ambroxol, which facilitates various steps in the biosynthesis of pulmonary surfactant, theophylline-7 acetic acid whose carrier function raises blood levels of ambroxol, thus rapidly and intensely stimulating surfactant production. The resulting reduction in the viscosity and adhesivity of the mucus greatly improves ciliary clearance. By deviating phosphatidylcholine towards surfactant synthesis, making it no longer available for the synthesis of inflammatory mediators such as the leukotrienes, acebrophylline also exerts an inflammatory effect. This is confirmed in vivo by the reduction in aspecific bronchial hyper-responsiveness in patients with stable bronchial asthma. On a clinical level, acebrophylline is therapeutically effective in patients with acute or chronic bronchitis, chronic obstructive or asthma-like bronchitis and recurrence of chronic bronchitis; it reduces the frequency of episodes of bronchial obstruction and reduces the need for beta2-agonists, and improves indexes of ventilatory function- Monaldi Arch Chest Dis. 2007 Jun;67(2):106-15.
Description : Terbutaline is Selective Beta 2 - Adrenerigc Agonist thus relaxes bronchaial smooth muscle.
Bromhexin is a potent mucokinetic and secretaolytic.
Guaifenasin is an expectorant that increases the volume and reduces the viscosity of secretions.
Sorbitol is used as Sweetener, a sugar substitute and a solvent and is safe for the diabetics.
Description : Cardiovascular side effects are less with Acebrophylline compared to Sustained Release Theophylline in Patients of COPD - J Clin Diagn Res.2014 Sep; 8(9)
